Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307749 | 1.00 | TSHR (0.42) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9308199 | 0.97 | ALDH1A1 (0.43) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9308161 | 0.97 | ALDH1A1 (0.43) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9307113 | 0.94 | TSHR (0.43) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9307826 | 0.90 | ALDH1A1 (0.43) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9307597 | 0.90 | ALDH1A1 (0.43) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9307082 | 0.90 | SMN1; SMN2 (0.46) | TSHRRECQLLMNASMN1; SMN2MTNR1A | |
| Iodide SCHEMBL9305409 | 0.90 | SMN1; SMN2 (0.46) | TSHRRECQLLMNASMN1; SMN2MTNR1A | |
| Iodide SCHEMBL9306785 | 0.90 | TSHR (0.44) | TSHRRECQLLMNAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL9307225 | 0.90 | TSHR (0.44) | TSHRRECQLLMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |