Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307825 | 1.00 | THRA (0.44) | THRATHRBS1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9306499 | 0.91 | THRA (0.43) | THRATHRBS1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9307774 | 0.91 | THRA (0.43) | THRATHRBS1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9307588 | 0.91 | THRA (0.43) | THRATHRBS1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9306302 | 0.91 | THRA (0.43) | THRATHRBS1PR2S1PR1S1PR3 | |
| Iodide SCHEMBL9307894 | 0.89 | SMPD1 (0.47) | THRATHRBSMPD1SMN1; SMN2NPSR1 | |
| Iodide SCHEMBL9306850 | 0.87 | THRA (0.46) | THRATHRBFAAHSMPD1SMN1; SMN2 | |
| Iodide SCHEMBL9308099 | 0.87 | THRA (0.46) | THRATHRBFAAHSMPD1SMN1; SMN2 | |
| Iodide SCHEMBL9306238 | 0.81 | SMPD1 (0.47) | THRATHRBSMPD1SMN1; SMN2NPSR1 | |
| Iodide SCHEMBL9307547 | 0.80 | SMPD1 (0.47) | THRATHRBSMPD1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |