Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9305107 | 0.94 | TSHR (0.42) | TSHRRECQLNPSR1THRATHRB | |
| Iodide SCHEMBL9306593 | 0.94 | TSHR (0.42) | TSHRRECQLNPSR1THRATHRB | |
| Iodide SCHEMBL9305585 | 0.90 | TSHR (0.43) | TSHRRECQL | |
| Iodide SCHEMBL9308322 | 0.90 | TSHR (0.43) | TSHRRECQL | |
| Iodide SCHEMBL9307722 | 0.89 | SMN1; SMN2 (0.46) | TSHRRECQLMTNR1A | |
| Iodide SCHEMBL9307113 | 0.89 | TSHR (0.43) | TSHRRECQLMTNR1A | |
| Iodide SCHEMBL9305539 | 0.87 | TSHR (0.53) | TSHRRECQLMTNR1A | |
| Iodide SCHEMBL9307597 | 0.85 | ALDH1A1 (0.43) | TSHRRECQLMTNR1A | |
| Iodide SCHEMBL9307320 | 0.85 | PLA2G4B (0.46) | — | |
| Iodide SCHEMBL9307826 | 0.85 | ALDH1A1 (0.43) | TSHRRECQLMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |