Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9305971 | 1.00 | POLB (0.50) | POLBTHRATHRBSMPD1S1PR2 | |
| Iodide SCHEMBL9308127 | 0.93 | POLB (0.51) | POLBTHRATHRBSMPD1 | |
| Iodide SCHEMBL9308472 | 0.93 | POLB (0.51) | POLBTHRATHRBSMPD1 | |
| Iodide SCHEMBL9307938 | 0.89 | SMPD1 (0.54) | SMPD1 | |
| Iodide SCHEMBL9306603 | 0.89 | SMPD1 (0.54) | SMPD1 | |
| Iodide SCHEMBL9307001 | 0.89 | SMPD1 (0.54) | SMPD1 | |
| Iodide SCHEMBL9307415 | 0.89 | POLB (0.52) | POLBTHRATHRBSMPD1 | |
| Iodide SCHEMBL9305941 | 0.89 | POLB (0.52) | POLBTHRATHRBSMPD1 | |
| Iodide SCHEMBL9306857 | 0.88 | THRA (0.49) | THRATHRBSMPD1 | |
| Iodide SCHEMBL9307302 | 0.88 | THRA (0.49) | THRATHRBSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |