Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.68 |
| ▸ | DRD3 | P35462 | 7/20 | 0.68 |
| ▸ | DRD4 | P21917 | 6/20 | 0.68 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HTR5A | P47898 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9309477 | 1.00 | DRD2 (0.68) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL9307960 | 1.00 | DRD2 (0.68) | DRD2DRD3DRD4HTR1AMEN1 | |
| Bromide SCHEMBL9306611 | 0.99 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AMEN1 | |
| Bromide SCHEMBL9306608 | 0.99 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL9308529 | 0.99 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL9307577 | 0.93 | DRD2 (0.60) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL9307575 | 0.93 | DRD2 (0.60) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL9307782 | 0.88 | DRD2 (0.55) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL9308072 | 0.88 | DRD2 (0.55) | DRD2DRD3DRD4HTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL11103097 | 0.86 | DRD2 (0.52) | DRD2DRD3DRD4HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4876284-A | CENTRAL NERVOUS SYSTEM DISORDERS | PER ARVID EMIL CARLSSON (SE) | 1989-10-24 | — | — | US | claimed |
| EP-0064964-B1 | THERAPEUTICALLY USEFUL 1-ALKYL-2-AMINOTETRALIN DERIVATIVES | Astra Läkemedel Aktiebolag (SE) | 1984-08-08 | — | — | EP | claimed |
| EP-0064964-A1 | Therapeutically useful 1-alkyl-2-aminotetralin derivatives | Astra Läkemedel Aktiebolag (SE) | 1982-11-17 | — | — | EP | claimed |
| US-5286747-A | 1-alkyl-2-aminotetralin derivatives | Carlsson, Per A. E. (SE) | 1994-02-15 | — | — | US | disclosed |
| US-4876284-A | CENTRAL NERVOUS SYSTEM DISORDERS | PER ARVID EMIL CARLSSON (SE) | 1989-10-24 | — | — | US | disclosed |
| EP-0064964-B1 | THERAPEUTICALLY USEFUL 1-ALKYL-2-AMINOTETRALIN DERIVATIVES | Astra Läkemedel Aktiebolag (SE) | 1984-08-08 | — | — | EP | disclosed |
| EP-0064964-A1 | Therapeutically useful 1-alkyl-2-aminotetralin derivatives | Astra Läkemedel Aktiebolag (SE) | 1982-11-17 | — | — | EP | disclosed |