Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327070 | 0.82 | TSHR (0.54) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL7550163 | 0.80 | ALDH1A1 (0.58) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL8617659 | 0.79 | TSHR (0.47) | TSHRALDH1A1TDP1HSP90AA1MAPT | |
| SCHEMBL27658894 | 0.79 | ALDH1A1 (0.50) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL31276573 | 0.79 | TSHR (0.56) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL29372814 | 0.79 | TSHR (0.56) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL980707 | 0.79 | TSHR (0.56) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL505600 | 0.79 | TSHR (0.56) | TSHRALDH1A1TDP1HSP90AA1CA2 | |
| SCHEMBL6522579 | 0.79 | TSHR (0.56) | TSHRALDH1A1TDP1CA2LMNA | |
| SCHEMBL8664622 | 0.78 | TSHR (0.50) | TSHRALDH1A1TDP1HSP90AA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374629-A | A triene steroids as anticarcinogenic agents, treating skin disorders | LEO PHARMACEUTICAL PRODUCTS LTD. A/S LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 1994-12-20 | — | — | US | disclosed |
| EP-0522013-B1 | NOVEL VITAMIN D ANALOGUES | LEO PHARM PROD LTD (DK) | 1994-11-23 | — | — | EP | disclosed |
| EP-0522013-A1 | NOVEL VITAMIN D ANALOGUES. | LEO PHARM PROD LTD (DK) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991015475-A1 | NOVEL VITAMIN D ANALOGUES | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1991-10-17 | — | — | WO | disclosed |