SCHEMBL9308498

SCHEMBL9308498

Cc1cc(OCCOCCO)cc(OCCOCCO)c1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.49
ALOX15 P16050 1/20 0.49
LMNA P02545 2/20 0.46
APP P05067 5/20 0.45
MAPK1 P28482 3/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
ALDH1A1 P00352 2/20 0.45
USP2 O75604 1/20 0.45
CYP3A4 P08684 1/20 0.45
CASP1 P29466 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
SLCO1B3 Q9NPD5 1/20 0.45
SLCO1B1 Q9Y6L6 1/20 0.45
TSHR P16473 2/20 0.43
HTR1A P08908 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.40
HTR7 P34969 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8672402 0.85 TP53 (0.47) TP53ALOX15LMNAMAPK1MEN1
SCHEMBL8673129 0.85 TP53 (0.47) TP53ALOX15LMNAMAPK1MEN1
SCHEMBL13699327 0.84 APP (0.40) TP53ALOX15LMNAAPPMAPK1
SCHEMBL10359827 0.83 TP53 (0.59) TP53ALOX15MEN1KMT2AALDH1A1
SCHEMBL10000093 0.82 MAPK1 (0.60) LMNAMAPK1KMT2AALDH1A1SMN1; SMN2
SCHEMBL10000094 0.82 MAPK1 (0.60) LMNAMAPK1KMT2AALDH1A1SMN1; SMN2
SCHEMBL13413138 0.82 KDM4E (0.42) TP53ALOX15LMNAMAPK1MEN1
SCHEMBL12725803 0.81 TSHR (0.63) LMNAAPPMAPK1MEN1KMT2A
SCHEMBL9310036 0.80 APP (0.57) LMNAAPPMAPK1MEN1KMT2A
SCHEMBL11810051 0.80 APP (0.57) LMNAAPPMAPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5331098-A Mono- and di(functionally-substituted phenylene) semi-rigid crowns and precursors thereof VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1994-07-19 US disclosed
EP-0494925-A4 POLYMERIZABLE (FUNCTIONALLY-SUBSTITUTED PHENYLENE) SEMI-RIGID CROWNS 1993-01-20 EP disclosed
US-5142068-A MONO- AND DI(FUNCTIONALLY-SUBSTITUTED PHENYLENE) SEMI-RIGID CROWNS AND PROCESSES FOR MAKING VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1992-08-25 US disclosed
EP-0494925-A1 POLYMERIZABLE (FUNCTIONALLY-SUBSTITUTED PHENYLENE) SEMI-RIGID CROWNS VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1992-07-22 EP disclosed
WO-1991004971-A1 POLYMERIZABLE (FUNCTIONALLY-SUBSTITUTED PHENYLENE) SEMI-RIGID CROWNS VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 1991-04-18 WO disclosed