Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 10/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923883 | 0.86 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6924103 | 0.82 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL936439 | 0.82 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL936438 | 0.82 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL938258 | 0.82 | PRKD1 (0.85) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6924074 | 0.80 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL937974 | 0.80 | PRKD1 (0.72) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL936479 | 0.80 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6923622 | 0.79 | PRKD1 (0.80) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL935616 | 0.78 | PRKD1 (0.79) | PRKD1PRKD3PRKD2ATMATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |