Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004656 | 0.86 | KDM4C (0.36) | KDM4CNPC1RAB9AGRM5GCK | |
| SCHEMBL9309965 | 0.82 | MEN1 (0.31) | KDM4CGRM5 | |
| SCHEMBL9164573 | 0.82 | MEN1 (0.31) | KDM4CGRM5 | |
| SCHEMBL9308408 | 0.81 | KDM4C (0.33) | KDM4CNPC1RAB9AGRM5 | |
| SCHEMBL11812965 | 0.81 | KDM4C (0.33) | KDM4CNPC1RAB9AGRM5GCK | |
| SCHEMBL10576592 | 0.78 | MEN1 (0.38) | KDM4CNPC1RAB9AGRM5GCK | |
| SCHEMBL6335488 | 0.75 | MEN1 (0.35) | KDM4CNPC1RAB9AGRM5GCK | |
| SCHEMBL6167587 | 0.75 | KDM4C (0.33) | KDM4CNPC1RAB9AGRM5GCK | |
| SCHEMBL10560537 | 0.74 | MEN1 (0.41) | KDM4CNPC1RAB9A | |
| SCHEMBL1227411 | 0.73 | MEN1 (0.34) | KDM4CNPC1RAB9AGRM5GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5318989-A | Antitumor and -carcinogenic agents; antibiotics; aglycones of esperamycins and calichemicins and having the same mechanism of bioactivity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0538898-A2 | Cytotoxic bicyclo (7.3.1)-tridec-4-ene-2,6-diyne compounds and process for the preparation thereof | Bristol-Myers Squibb Company (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5198560-A | Antitumor agents based on esperamicin antibiotics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0454146-A1 | Cytotoxic bicyclo[7.3.1] tridec-4-ene-2,6-diyne compounds and process for the preparation thereof | Bristol-Myers Squibb Company (US) | 1991-10-30 | — | — | EP | disclosed |