Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550394 | 0.79 | TSHR (0.36) | CYP1A2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL9309312 | 0.73 | MAOB (0.57) | MAOBMAOAALDH1A1 | |
| SCHEMBL9226415 | 0.69 | CYP1A2 (0.57) | CYP1A2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL7822962 | 0.63 | CYP1A2 (0.63) | CYP1A2MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL29038987 | 0.63 | CYP1A2 (0.49) | CYP1A2MAOBMAOADYRK1AKDM4E | |
| SCHEMBL15704191 | 0.63 | CYP1A2 (0.57) | CYP1A2MAOAKDM4EALDH1A1HPGD | |
| SCHEMBL26794228 | 0.62 | TSHR (0.38) | CYP1A2DYRK1AKDM4ETSHRNPSR1 | |
| SCHEMBL1232348 | 0.61 | TSHR (0.48) | DYRK1AKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL306406 | 0.61 | AR (0.42) | MAOBMAOAALDH1A1HPGDTSHR | |
| SCHEMBL8404426 | 0.61 | CYP1A2 (0.46) | CYP1A2MAOBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| CN-1052672-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1991-07-03 | — | — | CN | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |