Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 16/20 | 0.57 |
| ▸ | MAOA | P21397 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481860 | 0.78 | MAOB (0.62) | MAOBMAOACHRM2CHRM4CHRM5 | |
| SCHEMBL9309318 | 0.73 | CYP1A2 (0.33) | MAOBMAOAALDH1A1 | |
| SCHEMBL14231743 | 0.71 | MAOB (0.71) | MAOBMAOACHRM2CHRM4CHRM5 | |
| SCHEMBL19448665 | 0.68 | MAOB (0.47) | MAOBMAOACHRM2CHRM4CHRM5 | |
| SCHEMBL8993319 | 0.67 | MAOB (0.77) | MAOBMAOAALDH1A1 | |
| SCHEMBL8025307 | 0.67 | CYP2A6 (0.58) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL8179409 | 0.67 | MAOB (0.48) | MAOBMAOACHRM2CHRM4CHRM5 | |
| SCHEMBL9859939 | 0.67 | MAOB (0.47) | MAOBMAOACA1CA2CA9 | |
| SCHEMBL3983367 | 0.66 | MAOB (1.00) | MAOBMAOAALDH1A1ADORA3 | |
| SCHEMBL11850978 | 0.65 | MAOB (0.80) | MAOBMAOACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374646-A | Treatment or prophylasix of hypertension and diseases associated with cognitive disorders | GLAXO GROUP LIMITED (GB) | 1994-12-20 | — | — | US | disclosed |
| CN-1052672-A | Benzofuran derivative | GLAXO GROUP LTD (GB) | 1991-07-03 | — | — | CN | disclosed |
| EP-0434249-A2 | Benzofuran derivatives | GLAXO GROUP LIMITED (GB) | 1991-06-26 | — | — | EP | disclosed |