Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ABCC5 | O15440 | 2/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PDE9A | O76083 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE6C | P51160 | 2/20 | 0.57 |
| ▸ | PDE1A | P54750 | 2/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | PDE8A | O60658 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313876 | 0.87 | KMT2A (0.70) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL29655374 | 0.86 | KMT2A (0.83) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL1071 | 0.86 | KMT2A (0.83) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL1409 | 0.86 | PDE5A (0.78) | PDE5AABCC5PDE3BPDE3APDE2A | |
| SCHEMBL30848766 | 0.86 | PDE5A (0.78) | PDE5AABCC5PDE3BPDE3APDE2A | |
| SCHEMBL1253 | 0.85 | KMT2A (0.73) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL31202676 | 0.85 | KMT2A (0.73) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL25013468 | 0.82 | PDE5A (0.76) | PDE5AKMT2APDE3BPDE3APDE6C | |
| SCHEMBL22791902 | 0.82 | PDE5A (0.70) | PDE5AKMT2APOLBKDM4EABCC5 | |
| SCHEMBL1529 | 0.81 | PDE5A (1.00) | PDE5AKMT2APOLBKDM4EABCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |