Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | CCR3 | P51677 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8183381 | 0.77 | DRD3 (0.65) | HTR2ADRD3HTR1ADRD4DRD2 | |
| SCHEMBL5405231 | 0.77 | HTR2A (1.00) | HTR2AHTR2CCCR3HTR1ADRD4 | |
| SCHEMBL5847647 | 0.77 | HTR2A (1.00) | HTR2AHTR2CCCR3HTR1ADRD4 | |
| SCHEMBL9307016 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9307027 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9307633 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9307021 | 0.77 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL11856580 | 0.76 | HTR2A (0.69) | HTR2AHTR2CCCR3HTR1ADRD4 | |
| SCHEMBL13904324 | 0.76 | HTR2A (0.64) | HTR2AHTR2CCCR3HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL9308495 | 0.76 | SIGMAR1 (1.00) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294618-A | Psychological disorders | MERCK SHARP & DOHME LIMITED (GB) | 1994-03-15 | — | — | US | disclosed |
| EP-0410535-A2 | Octahydrobenzisoquinoline derivatives as antipsychotic agents | MERCK SHARP & DOHME LTD. (GB) | 1991-01-30 | — | — | EP | disclosed |