Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885301 | 1.00 | EPHX1 (0.60) | EPHX1CA12CA1CA2MMP2 | |
| SCHEMBL27666541 | 1.00 | EPHX1 (0.60) | EPHX1CA12CA1CA2MMP2 | |
| SCHEMBL2055562 | 1.00 | EPHX1 (0.60) | EPHX1CA12CA1CA2MMP2 | |
| Hydrochloric Acid SCHEMBL6758598 | 0.98 | EPHX1 (0.58) | EPHX1CA12CA1CA2MMP2 | |
| SCHEMBL5973016 | 0.98 | EPHX1 (0.58) | EPHX1CA12CA1CA2MMP2 | |
| Hydrochloric Acid SCHEMBL5392442 | 0.98 | EPHX1 (0.58) | EPHX1CA12CA1CA2MMP2 | |
| SCHEMBL930716 | 0.98 | EPHX1 (0.56) | EPHX1CA12CA1CA2MMP2 | |
| Hydrochloric Acid SCHEMBL5928655 | 0.96 | EPHX1 (0.56) | EPHX1CA12CA1CA2MMP2 | |
| SCHEMBL930588 | 0.93 | — | — | |
| SCHEMBL11682920 | 0.87 | ALOX5 (0.48) | EPHX1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011000945-A2 | AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS | NENSIUS RESEARCH A/S (DK) | 2011-01-06 | — | — | WO | claimed |
| WO-2012163456-A1 | NOVEL P2X7R ANTAGONISTS AND THEIR USE | AFFECTIS PHARMACEUTICALS AG (DE) | 2012-12-06 | — | — | WO | disclosed |
| WO-2011000945-A9 | AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS | NENSIUS RESEARCH A/S (DK) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011000945-A2 | AMINOALKAMIDES FOR USE IN THE TREATMENT OF INFLAMMATORY, DEGENERATIVE OR DEMYELINATING DISEASES OF THE CNS | NENSIUS RESEARCH A/S (DK) | 2011-01-06 | — | — | WO | disclosed |