Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL7290159 | 0.91 | ALDH1A1 (0.66) | ALDH1A1TSHRCA12HPGDMEN1 | |
| SCHEMBL68381 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRCA12HPGDMEN1 | |
| SCHEMBL29699944 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRCA12HPGDMEN1 | |
| Hydrochloric Acid SCHEMBL27731300 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TSHRCA12HPGDMEN1 | |
| SCHEMBL30360988 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TSHRCA12HPGDMEN1 | |
| Carbamic Acid SCHEMBL28367932 | 0.82 | ALDH1A1 (0.59) | ALDH1A1TSHRCA12HPGDMEN1 | |
| Acrylic Acid SCHEMBL28952727 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRCA12HPGDMEN1 | |
| SCHEMBL249846 | 0.77 | ALDH1A1 (0.68) | ALDH1A1TSHRCA12HPGDMEN1 | |
| SCHEMBL124981 | 0.77 | ALDH1A1 (0.67) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL29437308 | 0.77 | ALDH1A1 (0.67) | ALDH1A1TSHRHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334718-A | Decyclizing a phenyl or a pyridyl or pyrimidyl group by reacting with a base to get angiotension antagonist | ZENECA LIMITED (GB) | 1994-08-02 | — | — | US | disclosed |