Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312847 | 0.89 | TNKS (0.48) | POLBKMT2AMEN1RXFP1CASP3 | |
| SCHEMBL9312251 | 0.85 | TNKS (0.52) | POLBKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL9314224 | 0.84 | RAB9A (0.56) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL9312854 | 0.84 | RXFP1 (0.46) | POLBKMT2AMEN1RXFP1CASP3 | |
| SCHEMBL9312829 | 0.83 | TNKS (0.47) | POLBKMT2AMEN1RXFP1CASP3 | |
| SCHEMBL10477974 | 0.83 | POLB (0.61) | POLBKMT2AMEN1RXFP1CASP3 | |
| SCHEMBL9312911 | 0.81 | MAPT (0.51) | POLBKMT2AMEN1MAPTRAB9A | |
| SCHEMBL9313863 | 0.81 | MAPT (0.59) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL9313855 | 0.81 | MAPT (0.59) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL10587722 | 0.80 | KMT2A (0.56) | KMT2AMEN1KCNK9MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373019-A | Pharmaceutical lactam compositions for inhibition of erythrocyte and thrombocyte aggregation | BOEHRINGER MANNHEIM GMBH (DE) | 1994-12-13 | — | — | US | disclosed |
| US-4985448-A | Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-15 | — | — | US | disclosed |
| EP-0327986-A2 | Medicaments containing lactams, substituted lactams and process for their preparation | Roche Diagnostics GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |