Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.53 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312251 | 0.80 | TNKS (0.52) | TNKSTNKS2CITMAP3K7RIPK2 | |
| SCHEMBL3145019 | 0.80 | TNKS (0.56) | TNKSTNKS2CITMAP3K7RIPK2 | |
| SCHEMBL14073580 | 0.79 | KMT2A (0.66) | MALT1KMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL23674980 | 0.78 | MAP4K1 (0.61) | NR2E1ACLYMAP4K1ITGB1ITGA4 | |
| SCHEMBL30100785 | 0.78 | MAP4K1 (0.61) | NR2E1ACLYMAP4K1ITGB1ITGA4 | |
| SCHEMBL9312876 | 0.77 | POLB (0.57) | TNKSTNKS2KMT2AMEN1 | |
| SCHEMBL9312791 | 0.77 | TNKS (0.49) | TNKSTNKS2CITMAP3K7RIPK2 | |
| SCHEMBL14073807 | 0.77 | KMT2A (0.54) | ACLYMALT1ITGB1ITGA4CRBN | |
| SCHEMBL9313154 | 0.76 | TNKS (0.50) | TNKSTNKS2CITMAP3K7RIPK2 | |
| SCHEMBL9312847 | 0.76 | TNKS (0.48) | TNKSTNKS2CITMAP3K7RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373019-A | Pharmaceutical lactam compositions for inhibition of erythrocyte and thrombocyte aggregation | BOEHRINGER MANNHEIM GMBH (DE) | 1994-12-13 | — | — | US | disclosed |
| US-4985448-A | Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-15 | — | — | US | disclosed |
| EP-0327986-A2 | Medicaments containing lactams, substituted lactams and process for their preparation | Roche Diagnostics GmbH (DE) | 1989-08-16 | — | — | EP | disclosed |