Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943862 | 0.89 | BACE1 (0.63) | BACE1KCNH2BACE2APP | |
| SCHEMBL932718 | 0.87 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL932037 | 0.81 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL932274 | 0.78 | BACE1 (0.43) | BACE1KCNH2BACE2APP | |
| SCHEMBL1076369 | 0.78 | BACE1 (0.51) | BACE1KCNH2BACE2APP | |
| SCHEMBL931841 | 0.75 | BACE1 (0.70) | BACE1KCNH2BACE2APP | |
| SCHEMBL932157 | 0.72 | BACE1 (0.51) | BACE1KCNH2BACE2 | |
| SCHEMBL932355 | 0.72 | BACE1 (0.59) | BACE1KCNH2BACE2APP | |
| SCHEMBL932095 | 0.67 | BACE1 (0.78) | BACE1KCNH2BACE2 | |
| SCHEMBL1076368 | 0.67 | BACE1 (0.43) | BACE1KCNH2BACE2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |