Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.37 |
| ▸ | APP | P05067 | 6/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | CTSE | P14091 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075786 | 0.82 | BACE1 (0.58) | BACE1KCNH2APPBACE2 | |
| SCHEMBL1076369 | 0.79 | BACE1 (0.51) | BACE1KCNH2NPSR1APPBACE2 | |
| SCHEMBL932037 | 0.75 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL946110 | 0.73 | BACE1 (0.50) | BACE1KCNH2APPBACE2 | |
| SCHEMBL946601 | 0.71 | BACE1 (0.44) | BACE1KCNH2 | |
| SCHEMBL932718 | 0.71 | BACE1 (0.58) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932274 | 0.69 | BACE1 (0.43) | BACE1KCNH2NPSR1APPBACE2 | |
| SCHEMBL943862 | 0.67 | BACE1 (0.63) | BACE1KCNH2APPBACE2 | |
| SCHEMBL1076367 | 0.66 | ALDH1A1 (0.33) | — | |
| SCHEMBL1075789 | 0.65 | BACE1 (0.74) | BACE1KCNH2APPBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |