Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429727 | 0.85 | AGTR1 (0.43) | AGTR1ABCG2POLBSMN1; SMN2PTPRC | |
| SCHEMBL9430303 | 0.84 | AGTR1 (0.41) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL30743612 | 0.84 | ABCG2 (0.55) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4638846 | 0.83 | ABCG2 (0.46) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4638349 | 0.81 | AGTR1 (0.47) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL15391225 | 0.81 | AGTR1 (0.47) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9431379 | 0.81 | AGTR1 (0.39) | AGTR1ABCG2POLBSMN1; SMN2 | |
| SCHEMBL30786312 | 0.78 | HDAC8 (0.39) | AGTR1ABCG2POLBSMN1; SMN2MEN1 | |
| SCHEMBL3875056 | 0.78 | AGTR1 (0.49) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4638150 | 0.78 | AGTR1 (0.45) | AGTR1ABCG2POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5369114-A | Angiotensin II antagonist | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-11-29 | — | — | US | disclosed |
| EP-0456442-A1 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-11-13 | — | — | EP | disclosed |