Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.34 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834220 | 0.90 | NR1H4 (0.40) | MAPTPOLBNR1H4TP53PIK3CD | |
| SCHEMBL9831070 | 0.90 | NR1H4 (0.41) | MAPTPOLBNR1H4CCNA2CDK2 | |
| SCHEMBL9834320 | 0.90 | PIK3CD (0.39) | MAPTPOLBTP53PIK3CDPIK3R2 | |
| SCHEMBL9833961 | 0.90 | PIK3CD (0.40) | MAPTPOLBNR1H4TP53PIK3CD | |
| SCHEMBL9316748 | 0.90 | MAPT (0.44) | MAPTPOLBNR1H4TP53PIK3CD | |
| SCHEMBL9522451 | 0.89 | TP53 (0.49) | MAPTPOLBTP53USP2 | |
| SCHEMBL9833627 | 0.89 | PIK3CD (0.45) | MAPTPOLBNR1H4TP53PIK3CD | |
| SCHEMBL9524053 | 0.88 | MAPT (0.38) | MAPTPOLBTP53PIK3CDPIK3R2 | |
| SCHEMBL10568130 | 0.88 | MAPT (0.35) | MAPTPOLBNR1H4TP53PIK3CD | |
| SCHEMBL9833919 | 0.88 | PIK3CD (0.41) | MAPTPOLBPIK3CDPIK3R2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5352676-A | Morphalinomethyl-substituted 1-phenyl-indero-[1,2-c]pyrazol-3-yl derivatives of 2-cyano-3-oxo-propanamides useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1994-10-04 | — | — | US | disclosed |
| EP-0423269-B1 | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | ERBA CARLO SPA (IT) | 1994-01-12 | — | — | EP | disclosed |
| US-5260328-A | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis | FARMITALIA CARLO ERBA SRL (IT) | 1993-11-09 | — | — | US | disclosed |
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5196445-A | HETEROARYL-3-OXO-PROPANENITRILE DERIVATIVES USEFUL IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISEASES | FARMITALIA CARLO ERBA SRL (IT) | 1993-03-23 | — | — | US | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |