Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 9/20 | 0.46 |
| ▸ | PPARA | Q07869 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10480739 | 0.89 | KDM4E (0.50) | LMNATP53THRBKDM4EHPGD | |
| SCHEMBL10480768 | 0.83 | ACACB (0.41) | LMNATP53THRBHPGDMEN1 | |
| SCHEMBL9316506 | 0.82 | LMNA (0.47) | LMNATP53THRBKDM4EHPGD | |
| SCHEMBL9316424 | 0.81 | KDM4E (0.43) | LMNATP53THRBKDM4EHPGD | |
| SCHEMBL5795341 | 0.80 | KDM4E (0.54) | KDM4EHPGDPPARGPPARAPPARD | |
| SCHEMBL10480772 | 0.79 | KDM4E (0.53) | KDM4EHPGDPPARGPPARAPPARD | |
| SCHEMBL9316421 | 0.79 | MAPT (0.59) | LMNATP53THRBKDM4E | |
| SCHEMBL10480771 | 0.78 | KDM4E (0.52) | KDM4EHPGDPPARGPPARAPPARD | |
| SCHEMBL9316606 | 0.77 | POLB (0.55) | TP53THRBKDM4EPPARGPPARA | |
| SCHEMBL10480741 | 0.77 | KDM4E (0.40) | LMNATP53THRBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330998-A | Anticholesterol agents | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| EP-0389699-B1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER (US) | 1994-05-11 | — | — | EP | disclosed |
| EP-0389699-A1 | Thiazolidinedione derivatives as hypoglycemic agents | PFIZER INC. (US) | 1990-10-03 | — | — | EP | disclosed |