Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580715 | 0.80 | METAP1 (0.50) | METAP1CYP1A2SIGMAR1HPGDMETAP2 | |
| SCHEMBL7429602 | 0.80 | METAP1 (0.50) | METAP1CYP1A2SIGMAR1HPGDMETAP2 | |
| SCHEMBL13429375 | 0.76 | METAP1 (0.47) | METAP1CYP1A2SIGMAR1HPGDMETAP2 | |
| SCHEMBL7272902 | 0.76 | METAP1 (0.47) | METAP1CYP1A2SIGMAR1HPGDMETAP2 | |
| SCHEMBL6663470 | 0.76 | METAP1 (0.47) | METAP1CYP1A2SIGMAR1HPGDMETAP2 | |
| SCHEMBL5919195 | 0.76 | CYP1A2 (0.44) | METAP1CYP1A2SIGMAR1METAP2 | |
| SCHEMBL12321606 | 0.76 | METAP1 (0.57) | METAP1CYP1A2SIGMAR1METAP2TP53 | |
| SCHEMBL6934478 | 0.76 | METAP1 (0.57) | METAP1CYP1A2SIGMAR1METAP2TP53 | |
| SCHEMBL16306469 | 0.76 | METAP1 (0.57) | METAP1CYP1A2SIGMAR1METAP2TP53 | |
| SCHEMBL11692625 | 0.76 | METAP1 (0.47) | METAP1CYP1A2SIGMAR1HPGDMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6192160-A | — | — | None | — | — | JP | disclosed |
| CN-101395154-B | 8-azabicyclo [3.2.1] octane compounds as mu opioid receptor antagonists | THERAVANCE INC | 2011-01-19 | — | — | CN | disclosed |
| CN-101395154-A | 8-azabicyclo [3.2.1] octane compounds as mu opioid receptor antagonists | THERAVANCE INC (US) | 2009-03-25 | — | — | CN | disclosed |
| JP-H06192160-A | ZINGEROL DERIVATIVE AND CARDIOTONIC AGENT AND ENTEROKINESIS SUPPRESSING AGENT | NKK CORP | 1994-07-12 | — | — | JP | disclosed |