Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10467645 | 0.83 | MAPK1 (0.52) | KDM4EMAPK1GAALCKGABRP | |
| SCHEMBL25616497 | 0.82 | KDM4E (0.47) | KDM4EMAPK1GAAPOLBHSD17B10 | |
| SCHEMBL31216654 | 0.82 | KDM4E (0.56) | KDM4EMAPK1GAAPOLBGABRP | |
| SCHEMBL23704656 | 0.82 | MAPK1 (0.47) | KDM4EMAPK1LCKGABRPGABRD | |
| SCHEMBL30390198 | 0.81 | KDM4E (0.46) | KDM4EMAPK1GAALCKPOLB | |
| SCHEMBL20855864 | 0.81 | GAA (0.53) | KDM4EMAPK1GAAPOLBHSD17B10 | |
| SCHEMBL18512318 | 0.81 | KDM4E (0.46) | KDM4EMAPK1GAALCKPOLB | |
| SCHEMBL3408002 | 0.81 | MAPK1 (0.46) | KDM4EMAPK1GAALCKGABRP | |
| SCHEMBL9318646 | 0.80 | MAPK1 (0.49) | KDM4EMAPK1LCKGABRPGABRD | |
| SCHEMBL30836813 | 0.79 | MAPK1 (0.45) | KDM4EMAPK1LCKGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281943-B1 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1994-01-12 | — | — | EP | claimed |
| US-5004748-A | Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | claimed |
| US-5356909-A | Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-5143926-A | Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-09-01 | — | — | US | disclosed |
| US-5004748-A | Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-02 | — | — | US | disclosed |