Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964830 | 0.88 | NPC1 (0.54) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL17758464 | 0.83 | KMT2A (0.51) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL10942900 | 0.80 | KMT2A (0.45) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL11174467 | 0.80 | CA1 (0.54) | KMT2AMEN1LMNAALDH1A1ACHE | |
| SCHEMBL16450789 | 0.77 | KMT2A (0.46) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL9290768 | 0.77 | ALDH1A1 (0.41) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL1488883 | 0.77 | — | — | |
| SCHEMBL11724978 | 0.76 | KMT2A (0.46) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL12727665 | 0.75 | GAA (0.52) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| SCHEMBL17758549 | 0.74 | KMT2A (0.44) | KMT2AMEN1LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281597-A | Administering thiosemicarbazone or salt or suspension thereof to mammals | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1994-01-25 | — | — | US | disclosed |
| US-4777166-A | DIOL VEHICLE; HERPES VIRUS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1988-10-11 | — | — | US | disclosed |
| US-4739069-A | TREATMENT OF GONORRHEA, MALARIA, INFECTIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1988-04-19 | — | — | US | disclosed |
| US-4665173-A | ANTIMALARIAL, ANTILEUKEMIC | UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 1987-05-12 | — | — | US | disclosed |
| US-4657903-A | Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4596798-A | Herpes virus | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4493930-A | BACTERICIDES, ANTIMALARIA, AND ANTIGONORRHEA AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1985-01-15 | — | — | US | disclosed |
| US-4447427-A | PARTICULARLY GONORRHEA OR MALARIA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4401670-A | Method for treating gonorrhea infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-08-30 | — | — | US | disclosed |
| US-4385055-A | 2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1983-05-24 | — | — | US | disclosed |
| US-4317776-A | BACTERICIDES, ANTIMALARIAL, TREATMENT OF GONORRHEA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1982-03-02 | — | — | US | disclosed |