Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
| ▸ | TUBB | P07437 | 2/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320094 | 1.00 | MAPT (0.60) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL2451780 | 0.83 | MAPT (0.81) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL11354408 | 0.83 | MAPT (0.81) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL10941162 | 0.83 | MAPT (0.81) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL9320689 | 0.83 | MAPT (0.60) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL11716918 | 0.83 | MAPT (0.60) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL9320697 | 0.83 | MAPT (0.60) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL9322677 | 0.81 | BCHE (0.51) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL9322687 | 0.81 | BCHE (0.51) | MAPTLMNAKMT2ACYP3A4KDM4E | |
| SCHEMBL11720461 | 0.80 | MAPT (0.57) | MAPTLMNAKMT2ACYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440887-B1 | Improvement in the total synthesis of Erbstatin analogs | ERBA CARLO SPA (IT) | 1994-01-26 | — | — | EP | disclosed |
| US-5130472-A | TOTAL SYNTHESIS OF ERBSTATIN ANALOGS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-07-14 | — | — | US | disclosed |
| EP-0440887-A1 | Improvement in the total synthesis of Erbstatin analogs | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-14 | — | — | EP | disclosed |