Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | RRM2 | P31350 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11124858 | 0.85 | ALDH1A1 (0.41) | KDM4EL3MBTL1BTKRRM2ALOX15 | |
| SCHEMBL2622782 | 0.77 | RRM2 (0.50) | KDM4EL3MBTL1BTKRRM2 | |
| SCHEMBL11010879 | 0.77 | KDM4E (0.39) | KDM4EL3MBTL1BTKRRM2 | |
| SCHEMBL15029135 | 0.77 | ALDH1A1 (0.40) | KDM4EL3MBTL1 | |
| SCHEMBL2133032 | 0.77 | KDM4E (0.43) | KDM4EL3MBTL1BTKRRM2CHRM1 | |
| SCHEMBL30786115 | 0.77 | ALDH1A1 (0.40) | KDM4EL3MBTL1 | |
| SCHEMBL114699 | 0.77 | CYP11B1 (0.43) | — | |
| SCHEMBL14878746 | 0.77 | KDM4E (0.39) | KDM4EL3MBTL1BTKRRM2 | |
| SCHEMBL15007 | 0.77 | KDM4E (0.61) | KDM4EL3MBTL1BTKRRM2 | |
| SCHEMBL14059886 | 0.77 | KDM4E (0.39) | KDM4EL3MBTL1BTKRRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448934-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | AstraZeneca AB (SE) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002405-A1 | 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |