Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.63 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | DRD3 | P35462 | 4/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 5/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9319743 | 0.95 | SIGMAR1 (0.70) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL10504465 | 0.89 | SIGMAR1 (0.62) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL3500303 | 0.88 | SIGMAR1 (0.68) | SIGMAR1SLC6A2HRH3SLC6A4KCNH2 | |
| Hydrochloric Acid SCHEMBL14486498 | 0.86 | SIGMAR1 (0.66) | SIGMAR1TMEM97HRH1SLC6A2HRH3 | |
| Hydrochloric Acid SCHEMBL10503957 | 0.84 | SIGMAR1 (0.66) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL10507686 | 0.83 | SIGMAR1 (0.63) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL3251614 | 0.83 | SIGMAR1 (0.90) | SIGMAR1CCR3CYP1A2CYP2D6 | |
| SCHEMBL22561783 | 0.83 | HRH3 (0.74) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL10502864 | 0.80 | SIGMAR1 (0.66) | SIGMAR1DRD2TMEM97HTR1AHTR2A | |
| SCHEMBL2256688 | 0.80 | SIGMAR1 (0.59) | SIGMAR1DRD2SLC6A2HRH3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| EP-0524146-A1 | Aminosubstituted Piperazinederivatives | CIBA-GEIGY AG (CH) | 1993-01-20 | — | — | EP | disclosed |
| EP-0122488-B1 | BIS-(PIPERAZINYL- OR HOMOPIPERAZINYL)-ALKANES | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1989-06-07 | — | — | EP | disclosed |
| US-4725597-A | ANTIALLERGEN, ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM LTD. (US) | 1988-02-16 | — | — | US | disclosed |
| US-4722926-A | Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders | BOEHRINGER INGELHEIM LIMITED (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0127182-B1 | 1-PHENYLALKYL-4-(MERCAPTO AND CARBAMYLTHIO)ALKYL-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE IN THE TREATMENT OF ALLERGIC DISEASES | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1986-12-30 | — | — | EP | disclosed |
| US-4618677-A | Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl-thiols and -thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders | BOEHRINGER INGELHEIM LIMITED (US) | 1986-10-21 | — | — | US | disclosed |
| EP-0127182-A1 | 1-Phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0122488-A1 | Bis-(piperazinyl- or homopiperazinyl)-alkanes | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-10-24 | — | — | EP | disclosed |