SCHEMBL9320189

SCHEMBL9320189

O=Cc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1O

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
FFAR1 O14842 5/20 0.52
MEN1 O00255 1/20 0.51
TTR P02766 1/20 0.51
PPOX P50336 1/20 0.51
KMT2A Q03164 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
TRIM24 O15164 1/20 0.46
TYR P14679 1/20 0.46
TRIM33 Q9UPN9 1/20 0.46
HTR2A P28223 2/20 0.42
SLC6A4 P31645 2/20 0.42
KCNH2 Q12809 2/20 0.42
STK39 Q9UEW8 1/20 0.41
MRGPRX4 Q96LA9 6/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11124773 0.85 MEN1 (0.54) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL10615136 0.84 FFAR1 (0.55) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL32669004 0.84 FFAR1 (0.55) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL9827058 0.81 FFAR1 (0.48) MAPTFFAR1MEN1TTRPPOX
SCHEMBL8684467 0.81 FFAR1 (0.61) MAPTFFAR1MEN1TTRPPOX
SCHEMBL9827982 0.80 FFAR1 (0.46) POLBMAPTFFAR1MEN1TTR
SCHEMBL9827984 0.80 FFAR1 (0.46) POLBMAPTFFAR1MEN1TTR
SCHEMBL11436072 0.80 FFAR1 (0.52) FFAR1MEN1TTRPPOXKMT2A
SCHEMBL11309119 0.80 FFAR1 (0.57) POLBMAPTFFAR1MEN1TTR
SCHEMBL9506722 0.80 MEN1 (0.66) FFAR1MEN1TTRPPOXKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-6087783-A None JP disclosed
JP-6247897-A None JP disclosed
JP-4066548-A None JP disclosed
JP-4066549-A None JP disclosed
JP-H06247897-A PRODUCTION OF OPTICALLY ACTIVE PHENOXYCARBOXYLIC ACID DERIVATIVE TEIJIN LTD 1994-09-06 JP disclosed
JP-H0687783-A PRODUCTION OF ALDEHYDE DERIVATIVE USING PHOSPHORUS COMPOUND OR AMIDE COMPOUND TEIJIN LTD 1994-03-29 JP disclosed
EP-0533925-A1 OPTICAL ISOMER OF R-FORM OF DIPHENYL ETHER DERIVATIVE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1993-03-31 EP disclosed
JP-H0466548-A PRODUCTION OF ALDEHYDE DERIVATIVE TEIJIN LTD 1992-03-02 JP disclosed
JP-H0466549-A PRODUCTION OF OPTICALLY ACTIVE PHENOXYCARBOXYLIC ACID DERIVATIVE TEIJIN LTD 1992-03-02 JP disclosed
EP-0442172-A1 Oxime derivatives and Herbicides containing the same as an active ingredient TEIJIN LIMITED (JP) 1991-08-21 EP disclosed
EP-0433451-A1 OXIME DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS AN ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1991-06-26 EP disclosed
WO-1990001874-A1 OXIME DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS AN ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1990-03-08 WO disclosed