Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10456891 | 0.93 | HRH3 (0.70) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL10456895 | 0.92 | HRH3 (0.68) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8176206 | 0.90 | HRH3 (0.66) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8182732 | 0.89 | HRH3 (0.65) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8175825 | 0.89 | HRH3 (0.65) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL18883163 | 0.88 | HRH3 (0.59) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL727286 | 0.88 | HRH3 (0.64) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL28731828 | 0.87 | HRH3 (0.63) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL10458536 | 0.87 | ALDH1A1 (0.62) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 | |
| SCHEMBL10458541 | 0.82 | ALDH1A1 (0.67) | HRH3ALDH1A1SMN1; SMN2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-8648067-B2 | Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-8648067-B2 | Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON FRANCE (FR) | 2012-09-20 | — | — | US | disclosed |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON FRANCE (FR) | 2012-09-20 | — | — | US | disclosed |
| EP-2459529-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | Cephalon, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011002984-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002984-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | HRH3, HRH4, HRH2 | HRH3 1/4885ALDH1A1 2032/4885SMN1; SMN2 4805/4885 |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | HRH3, HRH4, HRH2 | HRH3 1/4885ALDH1A1 2032/4885SMN1; SMN2 4805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.