Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17891931 | 0.82 | — | — | |
| SCHEMBL667021 | 0.78 | — | — | |
| SCHEMBL4356969 | 0.76 | AKR1C3 (0.39) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL11240967 | 0.72 | LMNA (0.42) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL196906 | 0.72 | LMNA (0.42) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL771276 | 0.70 | KMT2A (0.35) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL4778694 | 0.67 | LMNA (0.50) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL20840303 | 0.67 | LMNA (0.50) | LMNATSHRCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL737197 | 0.67 | — | — | |
| SCHEMBL2303538 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0408714-B1 | HETEROCYCLIC SULPHONYLNITROMETHANES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | ICI PLC (GB) | 1994-01-26 | — | — | EP | disclosed |
| US-5096918-A | Aldose reductase inhibitors, diabetes, galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-17 | — | — | US | disclosed |
| EP-0408714-A1 | HETEROCYCLIC SULPHONYLNITROMETHANES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | ICI PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990008762-A1 | HETEROCYCLIC SULPHONYLNITROMETANES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-09 | — | — | WO | disclosed |