SCHEMBL932161

SCHEMBL932161

O=C(NCC1CN(c2ccc(C3=NOCCN3)cc2)C(=O)O1)c1ccc(Cl)s1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.66
F2 P00734 2/20 0.62
ABCB11 O95342 1/20 0.62
ST14 Q9Y5Y6 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL932159 1.00 F10 (0.66) F10F2ABCB11ST14
SCHEMBL4787218 0.88 F10 (0.68) F10F2ABCB11ST14
SCHEMBL4753182 0.86 F10 (0.67) F10F2ABCB11ST14
SCHEMBL4285179 0.82 F10 (0.68) F10F2ABCB11ST14
SCHEMBL4761182 0.82 F10 (0.74) F10F2ABCB11ST14
SCHEMBL7983945 0.82 F10 (0.43) F10F2ABCB11ST14
SCHEMBL4761157 0.81 F10 (0.66) F10F2ABCB11ST14
SCHEMBL4761205 0.81 F10 (0.66) F10F2ABCB11ST14
SCHEMBL77773 0.81 F10 (0.82) F10F2ABCB11ST14
SCHEMBL78408 0.81 F10 (0.82) F10F2ABCB11ST14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8637667-B2 Method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives LEGOCHEM BIOSCIENCE LTD. (KR) 2014-01-28 US disclosed
US-8637667-B2 Method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives LEGOCHEM BIOSCIENCE LTD. (KR) 2014-01-28 US disclosed
US-8637667-B2 Method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives LEGOCHEM BIOSCIENCE LTD. (KR) 2014-01-28 US disclosed
US-20120108808-A1 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2012-05-03 US disclosed
US-20120108808-A1 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2012-05-03 US disclosed
US-20120108808-A1 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2012-05-03 US disclosed
WO-2011005028-A3 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2011-05-19 WO disclosed
WO-2011005028-A3 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2011-05-19 WO disclosed
WO-2011005028-A2 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2011-01-13 WO disclosed
WO-2011005028-A2 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2011-01-13 WO disclosed
WO-2011005028-A2 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES LEGOCHEM BIOSCIENCE LTD. (KR) 2011-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108808-A1 METHOD FOR PREPARING (S)-5-CHLORO-N-((3-(4-(5,6-DIHYDRO-4H-1,2,4-OXADIAZIN-3-YL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)METHYL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES F2, F11, F5 F10 15/4885F2 1/4885ABCB11 4186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.