Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734102 | 0.86 | POLB (0.60) | KMT2AHTTSMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL23632182 | 0.85 | POLB (0.44) | KMT2ATSHRPOLBHCAR3CA1 | |
| SCHEMBL751536 | 0.81 | HCAR3 (0.60) | SMN1; SMN2TSHRPOLBHCAR3ALDH1A1 | |
| SCHEMBL20372325 | 0.79 | MAPT (0.50) | HTTL3MBTL1ALDH1A1PAX8MAPK1 | |
| SCHEMBL9365801 | 0.79 | POLB (0.47) | KMT2ATSHRPOLBHCAR3ALDH1A1 | |
| SCHEMBL14558232 | 0.77 | POLB (0.45) | KMT2ASMN1; SMN2TSHRPOLBHCAR3 | |
| SCHEMBL17075508 | 0.76 | HCAR3 (0.48) | CSNK2A2CSNK2BCSNK2A1TSHRL3MBTL1 | |
| SCHEMBL4953967 | 0.76 | CETP (0.42) | KMT2AHTTSMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL5586084 | 0.76 | POLB (0.42) | SMN1; SMN2TSHRPOLBHCAR3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9335654 | 0.76 | KMT2A (0.60) | KMT2AHTTSMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| EP-0524146-A1 | Aminosubstituted Piperazinederivatives | CIBA-GEIGY AG (CH) | 1993-01-20 | — | — | EP | disclosed |