Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 6/20 | 1.00 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 1.00 |
| ▸ | APP | P05067 | 9/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032043 | 0.96 | BACE1 (0.92) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL6892665 | 0.87 | BACE1 (0.80) | BACE1KCNH2BACE2APP | |
| SCHEMBL932165 | 0.83 | BACE1 (0.79) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931947 | 0.83 | BACE1 (1.00) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL943175 | 0.83 | BACE1 (1.00) | BACE1KCNH2BACE2APP | |
| SCHEMBL6894615 | 0.83 | BACE1 (0.73) | BACE1KCNH2BACE2APP | |
| SCHEMBL21307771 | 0.81 | BACE1 (0.68) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL18562653 | 0.81 | BACE1 (0.68) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931841 | 0.79 | BACE1 (0.70) | BACE1KCNH2BACE2APP | |
| SCHEMBL932581 | 0.79 | BACE1 (0.92) | BACE1KCNH2BACE2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |