Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932706 | 0.86 | BACE1 (0.66) | BACE1KCNH2CTSDADORA2AADORA1 | |
| SCHEMBL932551 | 0.84 | BACE1 (0.40) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932144 | 0.83 | BACE1 (0.46) | BACE1KCNH2CTSD | |
| SCHEMBL932682 | 0.83 | BACE1 (0.53) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932184 | 0.83 | BACE1 (0.48) | BACE1KCNH2CTSDADORA2AADORA1 | |
| SCHEMBL933481 | 0.77 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2ALDH1A1 | |
| SCHEMBL932676 | 0.76 | MAPT (0.38) | BACE1CTSDBACE2ALDH1A1 | |
| SCHEMBL6922254 | 0.73 | BACE1 (0.69) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932572 | 0.73 | BACE1 (0.69) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932844 | 0.72 | BACE1 (0.50) | BACE1KCNH2CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |