Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847231 | 0.87 | PPARG (0.53) | PPARGRARGRXRAHRH3PPARA | |
| SCHEMBL602342 | 0.85 | PPARG (0.67) | PPARGRARGRXRAPPARA | |
| SCHEMBL9326656 | 0.84 | HRH3 (0.48) | PPARGHRH3PPARAFFAR1 | |
| SCHEMBL6606406 | 0.84 | PPARG (0.66) | PPARGRARGRXRAPPARA | |
| SCHEMBL9121904 | 0.83 | MAPT (0.43) | PPARGRARGRXRAHRH3LTA4H | |
| SCHEMBL9535011 | 0.82 | PPARG (0.42) | PPARGRARGRXRAHRH3LTA4H | |
| SCHEMBL1415411 | 0.82 | PPARG (0.44) | PPARGRARGRXRAHRH3LTA4H | |
| SCHEMBL1847381 | 0.82 | PPARG (0.42) | PPARGRARGRXRAPPARA | |
| SCHEMBL6767115 | 0.82 | PPARG (0.49) | PPARGRARGRXRAHRH3LTA4H | |
| SCHEMBL1848107 | 0.82 | PPARG (0.47) | PPARGRARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415605-B1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | disclosed |
| US-5132317-A | Thiazolidinediones, Hypoglycemia Agents | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| EP-0415605-A1 | Thiazolidinedione derivatives | Beecham Group p.l.c. (GB) | 1991-03-06 | — | — | EP | disclosed |