Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803869 | 0.86 | FFAR1 (0.42) | HRH3FFAR1PPARGHPGDPPARA | |
| SCHEMBL10467351 | 0.86 | FFAR1 (0.42) | HRH3FFAR1PPARGHPGDPPARA | |
| SCHEMBL7911563 | 0.85 | HRH3 (0.42) | HRH3FFAR1PPARGHPGDPPARA | |
| SCHEMBL9325005 | 0.84 | PPARG (0.48) | HRH3FFAR1PPARGPPARA | |
| SCHEMBL4940660 | 0.83 | GAA (0.44) | — | |
| SCHEMBL8791799 | 0.83 | HPGD (0.54) | HRH3FFAR1PPARGHPGD | |
| SCHEMBL9143100 | 0.83 | HPGD (0.54) | HRH3FFAR1PPARGHPGDKMT2A | |
| SCHEMBL7898905 | 0.83 | HTR1B (0.42) | HRH3FFAR1PPARGPPARAKMT2A | |
| SCHEMBL9432799 | 0.83 | POLB (0.49) | KMT2AKDM4C | |
| SCHEMBL9535011 | 0.82 | PPARG (0.42) | HRH3FFAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415605-B1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | claimed |
| EP-0415605-A1 | Thiazolidinedione derivatives | Beecham Group p.l.c. (GB) | 1991-03-06 | — | — | EP | claimed |
| EP-0415605-B1 | Thiazolidinedione derivatives | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | disclosed |
| US-5132317-A | Thiazolidinediones, Hypoglycemia Agents | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| EP-0415605-A1 | Thiazolidinedione derivatives | Beecham Group p.l.c. (GB) | 1991-03-06 | — | — | EP | disclosed |