⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595691 | 0.72 | TRPA1 (0.32) | — | |
| SCHEMBL1760715 | 0.69 | — | — | |
| SCHEMBL6301594 | 0.69 | — | — | |
| SCHEMBL3092495 | 0.67 | — | — | |
| SCHEMBL711907 | 0.67 | — | — | |
| SCHEMBL3153322 | 0.67 | — | — | |
| SCHEMBL3092501 | 0.67 | — | — | |
| SCHEMBL2119365 | 0.67 | — | — | |
| SCHEMBL2492680 | 0.67 | — | — | |
| SCHEMBL4597138 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670244-B2 | Oxysterol compounds and the hedgehog pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| EP-1993558-B1 | OXYSTEROL COMPOUNDS AND THE HEDGEHOG PATHWAY | UNIV CALIFORNIA (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8022052-B2 | Inhibition of PPAR gamma expression by specific osteogenic oxysterols | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-20 | — | — | US | disclosed |
| WO-2011006087-A1 | INHIBITION OF PPAR GAMMA EXPRESSION IN PREADIPOCYTE CELLS BY OXYSTEROLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20100105645-A1 | INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100034781-A1 | Oxysterol Compounds and the Hedgehog Pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-02-11 | — | — | US | disclosed |
| EP-2111225-A2 | INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLS | The Regents Of The University Of California (US) | 2009-10-28 | — | — | EP | disclosed |
| EP-1993558-A2 | OXYSTEROL COMPOUNDS AND THE HEDGEHOG PATHWAY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008082520-A2 | INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-2007098281-A2 | OXYSTEROL COMPOUNDS AND THE HEDGEHOG PATHWAY | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-30 | — | — | WO | disclosed |