Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26374542 | 0.92 | ALDH1A1 (0.40) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL23627235 | 0.91 | ALDH1A1 (0.40) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL26374615 | 0.89 | ALDH1A1 (0.39) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL23627261 | 0.89 | ALDH1A1 (0.39) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL26381267 | 0.84 | ALDH1A1 (0.44) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL23627266 | 0.81 | ALDH1A1 (0.39) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL26374547 | 0.79 | ALDH1A1 (0.38) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL26381323 | 0.79 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL26374578 | 0.78 | ALDH1A1 (0.37) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD | |
| SCHEMBL26374612 | 0.77 | ALDH1A1 (0.37) | ALDH1A1LMNACYP3A4SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321186-B1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1994-03-02 | — | — | EP | disclosed |
| EP-0321187-B1 | 6-(SUBSTITUTED METHYLENE)PENEMS | BEECHAM GROUP PLC (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4931434-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-06-05 | — | — | US | disclosed |
| US-4923856-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-05-08 | — | — | US | disclosed |
| EP-0321186-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |
| EP-0321187-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |