SCHEMBL9325754

SCHEMBL9325754

O=C(Cl)c1ccc(Oc2ccccc2-c2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NCOA1 Q15788 1/20 0.58
NCOA3 Q9Y6Q9 1/20 0.58
FFAR4 Q5NUL3 3/20 0.52
PTGS2 P35354 1/20 0.48
FFAR1 O14842 1/20 0.47
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
FFAR2 O15552 1/20 0.45
FEN1 P39748 3/20 0.44
CAMKK2 Q96RR4 2/20 0.44
LMNA P02545 1/20 0.44
MAPK1 P28482 1/20 0.44
PARP10 Q53GL7 2/20 0.43
BRD4 O60885 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4326298 0.87 NCOA1 (0.62) NCOA1NCOA3FFAR4PTGS2FFAR1
SCHEMBL9483097 0.87 NCOA1 (0.62) NCOA1NCOA3FFAR4PTGS2FFAR1
SCHEMBL28092935 0.85 NCOA1 (0.60) NCOA1NCOA3FFAR4PTGS2FFAR1
SCHEMBL9243798 0.84 PARP10 (0.53) L3MBTL1FEN1LMNAMAPK1PARP10
SCHEMBL8993640 0.84 PARP10 (0.51) L3MBTL1FEN1MAPK1PARP10
SCHEMBL21310440 0.84 PARP10 (0.43) NCOA1NCOA3TDP1LMNAPARP10
SCHEMBL11418725 0.84 NCOA1 (0.58) NCOA1NCOA3FFAR4PTGS2FFAR1
SCHEMBL21178076 0.84 NCOA1 (0.58) NCOA1NCOA3FFAR4PTGS2RXRA
SCHEMBL30856503 0.83 FFAR4 (0.58) NCOA1NCOA3FFAR4PTGS2RXRA
Bicarbonate SCHEMBL28250947 0.83 NCOA1 (0.65) NCOA1NCOA3FFAR4PTGS2FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0314384-B1 Preparation of poly(arylene ether ketones) RAYCHEM CORP (US) 1994-02-02 EP disclosed
EP-0430994-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES). RAYCHEM CORP (US) 1991-06-12 EP disclosed
WO-1991002014-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1991-02-21 WO disclosed
US-4912181-A Preparation of poly(arylene ether ketones) by sequential oligomerization and polyerization in distinct reaction zones RAYCHEM CORPORATION (US) 1990-03-27 US disclosed
WO-1990001509-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1990-02-22 WO disclosed
WO-1990001510-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1990-02-22 WO disclosed
US-4874840-A DIGESTING IN WATER TO DESOLVENTIZE FOLLOWED BY HEAT TREATMENT RAYCHEM CORPORATION (US) 1989-10-17 US disclosed
US-4874839-A HEAT TREATMENT PRIOR TO MELT PROCESSING; DECOLORING; PURIFICATION RAYCHEM CORPORATION (US) 1989-10-17 US disclosed
US-4843131-A Preparation of poly(arylene ether ketones) by sequential oligomerization and polymerization in distinct reaction zones RAYCHEM CORPORATION (US) 1989-06-27 US disclosed
EP-0314384-A2 Preparation of poly(arylene ether ketones) RAYCHEM CORPORATION (a Delaware corporation) (US) 1989-05-03 EP disclosed