SCHEMBL8993640

SCHEMBL8993640

O=C(Cl)c1ccc(Oc2ccccc2Oc2ccc(C(=O)Cl)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 3/20 0.51
ALDH1A1 P00352 2/20 0.48
MAPK1 P28482 1/20 0.48
HTT P42858 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
TTR P02766 2/20 0.46
SRD5A2 P31213 3/20 0.46
RAB9A P51151 2/20 0.45
CTNNB1 P35222 1/20 0.44
PARP15 Q460N3 1/20 0.43
PARP14 Q460N5 1/20 0.43
PARP16 Q8N5Y8 1/20 0.43
PARP11 Q9NR21 1/20 0.43
PARP4 Q9UKK3 1/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
KCNQ3 O43525 1/20 0.42
KCNQ2 O43526 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9243798 0.96 PARP10 (0.53) PARP10ALDH1A1MAPK1HTTL3MBTL1
SCHEMBL11604084 0.87 LPAR1 (0.53) PARP10ALDH1A1HTTL3MBTL1HPGD
SCHEMBL9249310 0.85 PARP10 (0.64) PARP10ALDH1A1KMT2ASRD5A2RAB9A
SCHEMBL21786 0.85 PARP10 (0.64) PARP10ALDH1A1KMT2ASRD5A2RAB9A
SCHEMBL11044146 0.84 KMT2A (0.52) PARP10ALDH1A1MAPK1HTTL3MBTL1
SCHEMBL21310440 0.84 PARP10 (0.43) PARP10KMT2AMEN1TTRSRD5A2
SCHEMBL9325754 0.84 NCOA1 (0.58) PARP10MAPK1L3MBTL1FEN1
SCHEMBL272345 0.84 PARP10 (0.58) PARP10ALDH1A1HTTKMT2ASRD5A2
SCHEMBL9786679 0.84 PARP10 (0.58) PARP10ALDH1A1HTTKMT2ASRD5A2
Diphenylether SCHEMBL9717017 0.83 PARP10 (0.61) PARP10ALDH1A1SRD5A2RAB9AKCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5514769-A Aromatic polyamides containing keto-benzocyclobutene pendants THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1996-05-07 US disclosed
US-5264504-A Polyether ketone copolymers for molding materials THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1993-11-23 US disclosed
US-4229566-A FLEXIBLE STRONG FILMS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1980-10-21 US disclosed