Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.44 |
| ▸ | CHRNG | P07510 | 1/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423581 | 0.77 | C1S (1.00) | C1SPARP1SMN1; SMN2KMT2A | |
| SCHEMBL3178752 | 0.77 | C1S (0.63) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL29922182 | 0.76 | CHRNA1 (0.59) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3125040 | 0.76 | CHRNA1 (0.59) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3764471 | 0.75 | C1S (0.96) | C1SPARP1KMT2A | |
| SCHEMBL12599378 | 0.73 | C1S (0.59) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28685314 | 0.73 | PKM (0.52) | C1SALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL24934194 | 0.72 | C1S (0.63) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28879914 | 0.72 | C1S (0.52) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2221846 | 0.72 | C1S (0.57) | C1SPARP1ALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |