Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931620 | 0.86 | BACE1 (0.43) | BACE1KCNH2BACE2FYNMAPT | |
| SCHEMBL932603 | 0.84 | BACE1 (0.41) | BACE1KCNH2BACE2FYNMAPT | |
| SCHEMBL932404 | 0.80 | BACE1 (0.86) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL943241 | 0.74 | BACE1 (0.46) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL931686 | 0.74 | BACE1 (0.53) | BACE1KCNH2BACE2MAPTCTSD | |
| SCHEMBL931578 | 0.73 | BACE1 (0.45) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932572 | 0.73 | BACE1 (0.69) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL6922254 | 0.73 | BACE1 (0.69) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL943682 | 0.71 | BACE1 (0.47) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932245 | 0.70 | BACE1 (0.79) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |