Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932503 | 0.87 | BACE1 (0.67) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932706 | 0.82 | BACE1 (0.66) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932245 | 0.82 | BACE1 (0.79) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932046 | 0.79 | BACE1 (0.60) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL933242 | 0.79 | BACE1 (0.62) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932204 | 0.79 | BACE1 (0.67) | BACE1KCNH2BACE2 | |
| SCHEMBL933512 | 0.77 | BACE1 (0.63) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL945865 | 0.76 | ALDH1A1 (0.35) | BACE1BACE2CTSDMC4RMAPT | |
| SCHEMBL932108 | 0.75 | BACE1 (0.62) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932111 | 0.75 | BACE1 (0.47) | BACE1KCNH2BACE2CTSDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |