Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | NPC1 | O15118 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.67 |
| ▸ | RELA | Q04206 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327867 | 0.99 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9328817 | 0.99 | RAB9A (0.66) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9328588 | 0.96 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9325528 | 0.90 | SMN1; SMN2 (0.60) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9327815 | 0.89 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9326707 | 0.88 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9326991 | 0.88 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9327085 | 0.88 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9328544 | 0.88 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9328291 | 0.88 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361157-B1 | Phenyl pyridines | HOFFMANN LA ROCHE (CH) | 1994-03-02 | — | — | EP | disclosed |
| US-5284956-A | Liquid crystalline mixtures containing 2-(2-fluorophenyl) pyridines | HOFFMANN-LA ROCHE INC. (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0361157-A1 | Phenyl pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-04-04 | — | — | EP | disclosed |