Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811555 | 0.80 | SLC6A4 (0.66) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL6496199 | 0.76 | SLC6A2 (0.66) | HRH3SLC6A2SLC6A3SLC6A4MGLL | |
| SCHEMBL2888983 | 0.75 | ALDH1A1 (0.41) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL247758 | 0.74 | HRH3 (0.71) | HRH3GPR119 | |
| SCHEMBL593441 | 0.73 | HRH3 (0.44) | HRH3SLC6A2SLC6A3SLC6A4MGLL | |
| SCHEMBL7061476 | 0.73 | HRH3 (0.71) | HRH3GPR119 | |
| SCHEMBL506979 | 0.73 | HRH3 (0.71) | HRH3GPR119 | |
| SCHEMBL26049997 | 0.72 | SLC6A2 (0.66) | HRH3SLC6A2SLC6A3SLC6A4MGLL | |
| SCHEMBL25186010 | 0.71 | PARP10 (0.35) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL932285 | 0.71 | KMT2A (0.45) | HRH3SLC6A2SLC6A3SLC6A4LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |