Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932395 | 0.87 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL932924 | 0.85 | BACE1 (0.56) | BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL932889 | 0.84 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL970337 | 0.81 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL3696178 | 0.78 | BACE1 (0.58) | BACE1BACE2 | |
| SCHEMBL16056061 | 0.78 | BACE1 (0.44) | BACE1P4HTMHDAC3NCOR2 | |
| SCHEMBL16027180 | 0.77 | BACE1 (0.47) | BACE1BACE2 | |
| SCHEMBL16056613 | 0.75 | BACE1 (0.58) | BACE1BACE2 | |
| SCHEMBL933505 | 0.75 | CYP1A2 (0.36) | BACE1HDAC3NCOR2 | |
| SCHEMBL18192863 | 0.75 | BACE1 (0.58) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |