Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914630 | 0.82 | RECQL (0.55) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9529811 | 0.81 | RECQL (0.62) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23914631 | 0.80 | RECQL (0.60) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23966572 | 0.77 | RECQL (0.57) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23914889 | 0.76 | RECQL (0.56) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23915394 | 0.76 | RECQL (0.56) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23909042 | 0.75 | TSHR (0.55) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23915614 | 0.74 | GPR39 (0.62) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL5014224 | 0.74 | RECQL (0.83) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL23914729 | 0.74 | RECQL (0.53) | RECQLALDH1A1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304557-A | Aldose reductase inhibitor | PFIZER INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0436307-A1 | Substituted oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |
| WO-1991009019-A1 | SUBSTITUTED OXOPHTHALAZINYL ACETIC ACIDS AND ANALOGS THEREOF | PFIZER INC. (US) | 1991-06-27 | — | — | WO | disclosed |