Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9328579 | 0.86 | HTR2A (0.54) | CYP2D6CARM1PRMT6HTR2AKDM4E | |
| SCHEMBL9327527 | 0.84 | OPRM1 (0.50) | CYP2D6CARM1PRMT6HTR2AKDM4E | |
| SCHEMBL27014465 | 0.81 | CARM1 (0.56) | CYP2D6CARM1PRMT6HTR2AKDM4E | |
| SCHEMBL189154 | 0.77 | HTR2A (0.46) | CYP2D6CARM1PRMT6HTR2AKDM4E | |
| SCHEMBL9327579 | 0.77 | CHRM2 (0.49) | OPRM1 | |
| SCHEMBL6946061 | 0.74 | CYP2D6 (0.68) | CYP2D6MC4RDRD4OPRM1OPRK1 | |
| SCHEMBL3392214 | 0.74 | CARM1 (0.63) | CYP2D6CARM1PRMT6HTR2AKDM4E | |
| SCHEMBL19613224 | 0.74 | CYP2D6 (0.68) | CYP2D6MC4RDRD4OPRM1OPRK1 | |
| SCHEMBL7286703 | 0.74 | CYP2D6 (0.68) | CYP2D6MC4RDRD4OPRM1OPRK1 | |
| SCHEMBL19614197 | 0.74 | CYP2D6 (0.68) | CYP2D6MC4RDRD4OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325063-B1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMA (US) | 1994-03-09 | — | — | EP | claimed |
| US-4908369-A | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | claimed |
| EP-0337136-A2 | Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0319962-A2 | Piperidinyl methanol derivatives for the treatment of anxiety | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-06-14 | — | — | EP | claimed |
| EP-0325063-B1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5169096-A | Serotonin antagonists, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5106855-A | Method for the treatment of glaucoma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5021428-A | Novel chemical compounds for the prophylactic treatment of migraine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4912117-A | Therapy for varient angina | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | disclosed |
| US-4908369-A | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | disclosed |
| EP-0208235-B1 | N-ARALKYL PIPERIDINEMETHANOL DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0337136-A2 | Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0325063-A1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| EP-0319962-A2 | Piperidinyl methanol derivatives for the treatment of anxiety | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-06-14 | — | — | EP | disclosed |
| US-4783471-A | N-aralkyl piperidine methanol derivatives and the uses thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-11-08 | — | — | US | disclosed |