SCHEMBL9329045

SCHEMBL9329045

CCCCCCc1cc2c(cc1C#Cc1ccc(C(=O)OCC)cc1)C(C)(C)CC(C)(C)O2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.38
RARG P13631 2/20 0.38
RARA P10276 2/20 0.38
KMT2A Q03164 2/20 0.38
CYP3A4 P08684 1/20 0.38
PRKCA P17252 5/20 0.35
PRKCG P05129 1/20 0.35
PRKCB P05771 1/20 0.35
PRKCE Q02156 1/20 0.35
PRKCD Q05655 1/20 0.35
MAPT P10636 4/20 0.33
RAB9A P51151 3/20 0.33
KDM4E B2RXH2 1/20 0.33
NOD2 Q9HC29 1/20 0.33
TSHR P16473 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
ALDH1A1 P00352 4/20 0.33
NPC1 O15118 2/20 0.33
MMP13 P45452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9176298 0.93 RARA (0.40) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9179250 0.90 RARA (0.42) RARBRARGRARAKMT2ACYP3A4
SCHEMBL8865402 0.88 CYP3A4 (0.47) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9817799 0.86 RARB (0.42) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9180577 0.85 RARB (0.37) RARBRARGRARAKMT2ACYP3A4
SCHEMBL8629224 0.85 RARA (0.42) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9182162 0.84 CYP26A1 (0.41) RARBRARGALDH1A1HSD17B10
SCHEMBL9180571 0.83 RARB (0.42) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9180599 0.82 RARA (0.40) RARBRARGRARAKMT2ACYP3A4
SCHEMBL9176538 0.81 RARA (0.39) RARBRARGRARAKMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5278318-A Acetylation under Friedel Crafts condition ALLERGAN, INC. (US) 1994-01-11 US disclosed
EP-0553156-A4 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY 1993-11-18 EP disclosed
EP-0553156-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-04 EP disclosed
US-5162546-A ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-11-10 US disclosed
WO-1992006084-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed
US-4980369-A ANTIARTHRITIC AGENTS, SKIN DISORDERS, ANTIULCER AGENTS, WOUND HEALING AGENTS ALLERGAN, INC. (US) 1990-12-25 US disclosed